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CPT & Complexity – When to Start

A common concern expressed when planning CPT treatment is ‘when is the right time to start’. This is particularly the case for clients presenting with comorbid conditions and complex trauma histories where the themes of patient readiness, level of distress and dropout are expressed. There are two key considerations that emerge. The first is treating CPT where there is complexity; the second being whether stabilisation and management of other conditions should be completed prior to initiating CPT.

The question of complexity is frequently raised as a treatment complication, with genuine concerns that the presence of other conditions may inhibit or impact the treatment of PTSD with CPT. In practice, this is often found to be a clinician stuck point, with considerable evidence now supporting client’s abilities to complete CPT when comorbid diagnoses are present. These include depression, substance use, borderline personality disorder, and traumatic brain injury (TBI), and in our clinical settings, functional neurological disorder (FND) & somatic conditions have also been present. Multiple RCT’s have been conducted with broad inclusion criteria such as dissociation, panic, personality disorder, depression and substance use (for review, see Galovski, Nixon, & Kaysen, 2020). No differences in PTSD treatment gains have been found between those with or without borderline personality disorder diagnosis (Resick et al., 2002). Kaysen et al. (2014) found no outcome differences in those with current or past histories of alcohol use disorders and those without. To enhance outcomes for clients presenting with complexity, tailoring the dose of CPT therapy might need to be considered, with Galovski (2012) finding that an additional 26% of participants achieved a positive end state level of symptoms when given extra sessions (to a maximum of 18). This approach has been echoed with good result in an Australian outpatient public mental health clinic (in Victoria) where CPT is offered as part of routine care.

With complexity comes the question as to whether initial stabilisation is needed prior to commencing CPT. A recent study conducted in a US Veterans Affairs specialty PTSD clinic found that contrary to the intended role of preparatory treatments, they were actually associated with a worse treatment response for those who later received a trauma focused evidence-based psychotherapy such as CPT or Prolonged Exposure (Dedert et al., 2020). Participants who went directly into an Evidence Based Protocol (EBP) had a better treatment response for PTSD and depressive symptoms. In addition, the authors report that only a quarter of those enrolled in preparatory treatment progressed to engaging in a trauma focused EBP. Whilst it should be noted that this study did not have random allocation, and thus it is possible that veterans with greater levels of avoidance self selected into preparatory treatments and were also then less engaged in the subsequent EBP, the results add to the body of evidence that many patients benefit from immediate provision of evidence based treatments and do not always require stablisation or preparatory skill building work. As Dedert and colleagues note, there is a lack of data detailing what constitutes ‘readiness’ to benefit from trauma focused treatment, while in contrast, data indicate that clinical worsening occurs during waitlist conditions. These findings underscore the importance of shared decision making and treatment planning with clients to prioritise engagement in evidence based treatment early in the course of contact with clinical services.

References

Clarke, S.B., Rizvi, S.L., & Resick, P.A. (2008). Borderline personality characteristics and treatment outcome in cognitive-behavioral treatments for PTSD in female rape victims. Behavior Therapy, 39, 72-78.

Dedert, E.A., LoSavio, S.T., Wells, S.Y., Steel, A.L., Reinhardt, K., Deming, C.A., Ruffin, R.A., Berlin, K.L., Kimbnrel, N.A., Wilson, S.M., Boeding, S.W., & Clancy, C.P. (2020, August 27). Clinical Effectiveness Study of a Treatment to Prepare for Trauma‐Focused Evidence‐Based Psychotherapies at a Veterans Affairs Speciality Posttraumatic Stress Disorder Clinic. Psychological Services. Advance online publication http://dx.doi.org/10.1037/ser0000425

Galovski, T. E., Blain, L. M., Mott, J. M., Elwood, L., & Houle, T. (2012). Manualized therapy for PTSD: Flexing the structure of cognitive processing therapy. Journal of Consulting and Clinical Psychology, 80(6), 968-981. doi:10.1037/a0030600

Galovski, T.E., Nixon, R.D.V., & Kaysen, D. (2020). Flexible Applications of Cognitive Processing Therapy:Evidence‐Based Treatment Methods. Cambridge, MA, USA: Elsevier Science, an imprint of Academic Press.

Kaysen, D., Schumm, J., Pedersen, E.R., Seim, R.W., Bedard-Gilligan, M., & Chard, K (2014). Cognitive processing therapy for veterans with comorbid PTSD and alcohol use disorders. Addictive Behaviour, 39(2): 420-7.

Resick, P,A., Nishith, P.,  Weaver, T.L., Astin, M.C & Feuer, C.A  (2002). A comparison of cognitive-processing therapy with prolonged exposure and a waiting condition for the treatment of chronic posttraumatic stress disorder in female rape victims. Journal of Consulting and  Clinical Psychology, 70(4): 867-79.

Telehealth

Can I do CPT over video conferencing, will it be effective?

With the potential for people in rural and remote areas of Australia to now access services via video conferencing the question is, can Cognitive Processing Therapy delivered by video work?

There are now four noninferiority trials (yes trials to find out if video conference delivery was inferior or not) showing that Cognitive Processing Therapy (CPT) delivered via telehealth is just as effective as if delivered in person.

Morland et al (2014) tested Group CPT via telehealth with a sample of male Veterans, predominantly of the Vietnam era. They reported that clinical and process outcomes for CPT video conference were noninferior to CPT in-person treatment. Significant reductions in PTSD symptoms were identified at posttreatment and maintained at 3-month and 6-month follow-up. High levels of therapeutic alliance, treatment compliance, and satisfaction and moderate levels of treatment expectancies were reported, with no differences between video conference therapy and in person therapy groups.

Morland et al (2015) tested individual CPT+A with women, 20% of whom were veterans. They found improvements in PTSD symptoms in the CPT video conferencing condition were noninferior to outcomes in the in-person CPT therapy condition. Clinical outcomes obtained when both conditions were pooled together demonstrated that PTSD symptoms declined substantially posttreatment and gains were maintained at 3-month and 6-month follow-up. Veterans demonstrated smaller symptom reductions posttreatment than civilian women.

Maieritsch et al. 2015 tested individual CPT with Operation Iraqi Freedom and Operation Enduring Freedom veterans who were predominantly male. There were some limitations in this study, including a dropout rate of 43.3%. Despite this Maieritsch et al. 2015 reported that a trend was observed which suggested that CPT via video conference may be equivalent to the treatment delivered in person, as suggested by previous studies. Regardless of treatment, veterans who received the intervention in both conditions reported significant decreases on post-treatment measures.

Liu et al. (2019) examined veterans who had an average age of 48, almost 50% of the CPT video conferencing group had participated in World War two. They reported that both completer and intention to treat analyses showed that improvement in CAPS scores in the video conference condition was non-inferior to that in the in-person CPT therapy condition at six-month follow-up. Unlike the previous trials the video conferencing condition was inferior to in person therapy condition for improvement in CAPS at post-treatment. Non-inferiority was supported by completer analyses for PCL–S and PHQ–9 in both post-treatment change and six-month follow-up change, and the intention to treat analysis supported the significant non-inferiority for PCL at posttreatment change.

Summary
CPT can be effectively delivered by video conferencing facilities. More research is needed to understand differences in response over time.

References
Liu, L., Thorp, S. R., Moreno, L., Wells, S. Y., Glassman, L. H., Busch, A. C., . . . Agha, Z. (2019). Videoconferencing psychotherapy for veterans with PTSD: Results from a
randomized controlled non-inferiority trial. Journal of Telemedicine and Telecare. Advance online publication. PTSDpubs ID: 52097

Maieritsch, K. P., Smith, T. L., Hessinger, J. D., Ahearn, E. P., Eickhoff, J. C., & Zhao, Q. (2016). Randomized controlled equivalence trial comparing videoconference and in person delivery of cognitive processing therapy for PTSD. Journal of Telemedicine and Telecare, 22(4), 238-243. doi:http://dx.doi.org/10.1177/1357633X15596109

Morland, L. A., Mackintosh, M., Greene, C. J., Rosen, C. S., Chard, K. M., Resick, P., & Frueh, B. C. (2014). Cognitive processing therapy for posttraumatic stress disorder delivered to rural veterans via telemental health: A randomized noninferiority clinical trial. The Journal of Clinical Psychiatry, 75(5), 470-476. doi:http://dx.doi.org/10.4088/JCP.13m08842

Morland, L. A., Mackintosh, M., Rosen, C. S., Willis, E., Resick, P., Chard, K., & Frueh, B. C. (2015). Telemedicine versus in-person delivery of cognitive processing therapy for women with posttraumatic stress disorder: a randomized noninferiority trial. Depression and Anxiety, 32(11), 811-820. doi:http://dx.doi.org/10.1002/da.22397

Treating ptsd in the context of a jail – diversion program

An important question for clinicians is how well do evidence-based PTSD therapies work in the real world? In this article published in Psychological Services, Feingold and colleagues (2018) examined this with respect to both Cognitive Processing Therapy (CPT) and a generic form of Cognitive Behavioural Therapy (CBT).

Does this work for those in the criminal justice system in the presence of serious mental illness?

Well, the short answer is yes! As documented by Feingold, serious mental illness (SMI) such as schizophrenia, severe depression and bipolar is frequently accompanied by prior exposure and risk of trauma, with comorbid PTSD common. The clinical needs of this group of clients is compounded when clients are involved in the criminal justice system. For those with SMI, incarceration can lead to further traumatic exposure and victimization, as well as exacerbation of pre-existing psychiatric difficulties. Jail-diversion programs offers an unique window to address sufferers mental health, however the effectiveness of therapies for PTSD and trauma-related issues is unknown. Feingold et al. addressed this issue.

Clients diagnosed with PTSD received Cognitive Processing Therapy (n = 31), and those with trauma-related distress or problems but not diagnosed with PTSD, received CBT (n = 28). In the latter group, disorders such as depression were the typical focus of therapy. On average clients received 10-12 sessions. As would be expected, the sample had multiple comorbidities, significant trauma histories, and were not always living in stable settings. For example, 30% were either homeless or had transient housing arrangements.

Clinically significant reductions in PTSD and depression were observed. Not surprisingly those who were able to complete treatment had better outcomes. Dropout was 44%, somewhat expected due to the complexity of the sample, but appeared to be more a function of logistical issues and certain comorbidity reasons (e.g., substance relapse requiring focus), not inability to engage in trauma-related therapy. Although the findings are preliminary, and replication could address some of the study limitations (e.g., lack of no-treatment control, lack of follow-up assessment), they do demonstrate the short-term effectiveness of evidence-based approaches, including CPT, for challenging and complex samples.

Feingold, Z. R., Fox, A. B., & Galovski, T. E. (2018). Effectiveness of evidence-based psychotherapy for posttraumatic distress within a jail diversion program. Psychological Services, 15, 409-418. doi: 10.1037/ser0000194